Unfortunately, there has been a notable lack of activating mutations in driver oncogenes in SCLC, and molecularly targeted agents have yet to find a place in the treatment of SCLC. Studies have shown high somatic mutation rates and copy number alterations in the tumor tissues with a near-universal bi-allelic inactivation of TP53 and RB1. Several groups have pursued comprehensive genomic profiling of SCLC with hopes of identifying actionable genomic targets. As outcomes are poor, therapeutic options after relapse are limited. Despite a typically dramatic initial response to therapy, most patients with SCLC experience relapse within 6 months despite chemotherapy and radiation and the 5-year survival rates for patients with ES disease remain low (5%). Radiotherapy is traditionally reserved for the palliation of symptoms in patients with ES disease, and PCI remains controversial. For ES disease, the first-line chemotherapy for newly diagnosed metastatic SCLC consisted of a platinum agent (cisplatin or carboplatin) with etoposide. In patients who respond to initial treatment, prophylactic cranial irradiation (PCI) is also part of the standard management with non-metastatic disease. The standard chemotherapy regimen in this setting is cisplatin–etoposide. Chemotherapy can both augment the local efficacy of radiation and potentially treat micrometastatic disease. Local treatment options include surgery and radiotherapy. In non-metastatic SCLC, the therapeutic goals are to achieve durable control of thoracic disease and reduce the risk of metastatic dissemination. The initial approach to SCLC treatment varies substantially by stage. Although the tumor–node–metastasis (TNM) classification is preferred to the staging system of the Veterans Administration Lung Study Group (VALSG), which separates limited-stage (LS) disease (tumor confined to one hemi-thorax and one radiation port no malignant pleural or pericardial effusion) from extensive-stage (ES) disease (not meeting criteria for LS), the latest staging system is still widely used in both designing clinical trials and presenting data from them, as it effectively distinguishes patients treated primarily with chemotherapy (LS disease) from those treated with systemic chemotherapy or chemoimmunotherapy (ES disease). In these patients, systemic chemotherapy is typically the primary therapeutic modality, with some patients also drawing benefit from radiation therapy. Most patients have advanced disease and present with distant metastases, malignant effusions, and/or contralateral supraclavicular or hilar lymph node involvement. These two properties contribute to a particularly high mortality rate. In general, SCLC grows rapidly and has high metastatic potential. Small-cell lung cancer (SCLC) is a neuroendocrine tumor that represents about 13% of all lung cancers and occurs predominantly in smokers. With the therapeutic landscape for SCLC rapidly evolving, we review prior experience and future directions of pembrolizumab in ES-SCLC. In a recent clinical trial that included patients with previously untreated ES-SCLC, pembrolizumab in combination with platinum/etoposide met its progression-free survival endpoint, but overall survival (OS) did not cross the threshold for superiority. ![]() Food and Drug Administration (FDA) granting pembrolizumab accelerated approval as second- or third-line monotherapy for patients with extensive-stage (ES) SCLC. Prospective trials of pembrolizumab in patients with previously treated SCLC showed significant durability of responses. Pembrolizumab, a humanized IgG4 isotype antibody, targets the programmed cell death protein 1 (PD-1) pathway to restore anti-tumor immunity. The management of SCLC significantly changed for the first time in decades with the introduction of immune checkpoint inhibitors. Small-cell lung cancer (SCLC) is an aggressive subtype of lung cancer characterized by a rapid initial response and early development of resistance to systemic therapy and radiation.
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A children's Spanish musical duo, Enrique y Ana, made a song called "Caca Culo Pedo Pis", which literally translates to "Poop Butt Fart Pee". Examples of this are found in Mozart and scatology, and variants of the German folk schoolboys' song known as the Scheiße-Lied (English: "Shit-Song") which is indexed in the German Volksliederarchiv. Toilet humour is sometimes found in song and rhyme, particularly schoolboy songs. The humour comes from the rejection of such taboos, and is a part of modern culture. Toilet humour is commonly an interest of children and young teenagers, for whom cultural taboos related to acknowledgement of waste excretion still have a degree of novelty. It sees substantial crossover with sexual humour, such as dick jokes. Toilet humour, or potty or scatological humour (compare scatology), is a type of off-colour humour dealing with defecation, diarrhea, constipation, urination and flatulence, and to a lesser extent vomiting and other bodily functions. Otherwise we shall turn around and show you our rears." ![]() Caption reads: "Don't frighten us Pope, with your ban, and don't be such a furious man. ![]() German peasants respond to a papal bull of Pope Paul III. From a series of woodcuts (1545) usually referred to as the Papstspotbilder or Papstspottbilder in German or Depictions of the Papacy in English, by Lucas Cranach, commissioned by Martin Luther. Sold for $290,000 at auction, a buyer in the Midwest bought an original 1967 pressing of The Beatles’ most iconic album. Pepper's Lonely Hearts Club Band (signed by all four Beatles) - $290,000Ĭelebrities aren’t the only ones getting in on buying some of the most valuable and rare vinyl records in history. And in 2015, Jack White bought a test pressing of Elvis’ first recording for a reported $300,000 at auction, making it the third most valued vinyl record sale of all time. Elvis Presley: 'My Happiness' - $300,000Īs an artist who loves vinyl records, Jack White is also one of the most prolific musicians in this generation. With a print number of '0000001', the second most valuable vinyl record in history was sold at auction in the United States for $790,000. ![]() The Beatles: The Beatles (White Album) - $790,000Īs one of the Beatles’ most famous LPs, the band’s drummer Ringo Starr owned the first printing of this album from 1968. However, he’s allowed to release it free of charge. Because of his impropriety, he’s now behind bars for at least 20 years, pretty much ensuring he won’t be enjoying the most valued vinyl record of all time in the near future.Īnd even when he gets out, the terms of the buyer’s agreement stipulates that the buyer (Shkreli) may not release the album for profit for 100 years. Shkreli, the controversial former CEO of Turing Pharmaceuticals, hiked up the price of his company’s anti-HIV drug by more than 5000%. The infamous (and currently incarcerated) Martin Shkreli paid a reported $2 million for this 2015 album, of which Shkreli’s copy is the only one produced, making it the most valuable and rare vinyl album to date. Wu-Tang Clan: Once Upon a Time in Shaolin - $2 million The most valuable vinyl records of all time may not be the most widely released, but for a lucky few, these records were definitely worth (way more) than their weight in gold.Īccording to HMV, these are the top individual vinyl record sales of all time. In fact, the rarest vinyl records also end up as the most valued vinyl records that some collectors will pay seemingly any amount of money for. The same goes for some of the most rare vinyl albums. ![]() ![]() But what if money was no object? Prime collectibles like rare wines, antique cars, or fine art appreciate in value over time. Most vinyl lovers likely go online or head to a local record store to find their favorite albums. ![]() What are the benefits of having a 2 ton AC unit?Ī 2 ton AC unit can provide a number of benefits, including improved comfort levels, increased energy efficiency, and reduced noise levels. This cooled air is then circulated back into the room, providing a comfortable environment for occupants.Ģ. The refrigerant is compressed and evaporated in the unit's compressor, which then cools the air as it passes through the coils. How do they work? What are the benefits of having one? How much does a 2 ton AC unit cost? Here, we'll answer some of the most frequently asked questions about 2 ton AC units so that you can be an informed shopper.Ī 2 ton AC unit is a self-contained air conditioning system that uses refrigerant to cool and circulate air in a space. When it comes to AC units, there are a lot of questions out there. ![]() And if any problems should arise, you're covered by a limited warranty. Plus, with a 14 SEER rating, you can be sure that this Goodman unit is one of the most energy-efficient models on the market. This powerful unit uses air to operate, so you'll never have to worry about it overloading your electrical system. Accessories such as line sets, thermostats, LP conversion kits are sold separately.īest durable: Goodman GSX140241 - CAPF3636A6 Plus, it comes with a 10-year parts limited provided it is installed by a qualified installer and registered online. This listing includes the Goodman 2.5 Ton 14 SEER heat pump, Goodman 2 Ton multi-position air handler, and thermal expansion valve (TXV) for a 2-3 ton R-410a system. So don't wait any longer, beat the heat with the Goodman 2 Ton 14 SEER Air Conditioning System.īest for budget: Goodman GSZ140301-ARUF29B14-TX2N4 Plus, it comes with a 10-year parts limited warranty, so you can be assured of its quality and durability. This system is designed to deliver maximum cooling comfort while using minimal energy, so you can save money on your utility bills. Best for hot summer days: Goodman GSX140241 - ARUF29B14 ![]() Odds: Golden State favored +1, via Oddsshark. With both teams scoring at such high percentages, cutting down extra possessions and pushing the pace in transition become key factors for either side. With both teams shooting over 50 percent from the field there weren't many rebounds bouncing around the court, but the Warriors still managed to out-rebound the Nuggets, 36-26. With Jarrett Jack moving into the starting lineup, the Warriors have loaded their production into their starting five. Draymond Green, Festus Ezeli, Carl Landry, and Richard Jefferson make up the Warriors' reserves. Golden State's depth has been depleted, scoring only 24 points combined in Game 2. ![]() Andre Miller and Corey Brewer alone scored 37 for the Nuggets. ET, ABC Game 2: Nuggets Warriors, Monday, April 18, 10:00 p.m. Game 1: Nuggets Warriors, Saturday, April 16, 8:30 p.m. The key? Denver's bench combined for 62 points. Here’s how the schedule sets up for this first-round matchup, with Golden State having homecourt advantage as the higher seed. ![]() Nuggets coach Mike Malone praises his team's collective effort to take a 3-1 lead over the Heat. While the Warriors offense has been the topic of conversation, Denver scored more than enough to win in Game 2. Visit ESPN to view the Golden State Warriors team schedule for the current and previous seasons. Will Curry be able to push the pace and move on offense, or will it weigh him down and slow the Warriors offensive attack? If Curry's ankle impacts his speed, the Nuggets defense will be far less susceptible to the errors they committed in Game 2. There's also the issue of Curry's ankle, which has left him as a "game time decision" for Game 3. Curry was a willing passer in Game 2 and his teammates were hitting the open shots he set on the table for them. This interesting matchup between the Denver Nuggets and Miami Heat is the NBA Finals series no one saw. The Nuggets attempted to throw extra defense at Curry to slow down the prolific scorer, but only hurt themselves in the process. NBA Finals preview: Gear up for Nuggets vs. The Nuggets need to play smarter defense on Curry in Game 3 to avoid a loss on the road. The Nuggets and Warriors faced off four times during the regular season with Denver winning three games by an average of 3.7 points. Game 1: Thursday, June 1 (Nuggets won 104-93) Game 2: Sunday, June 4 (Heat won 111-108) Game 3: Wednesday, June 7 (Nuggets won 109-94) Game 4: Friday, June 9 at 8:30 p.m. So that’s what we’ll do.The Warriors dropped 131 points on the Nuggets in Game 2 while Stephen Curry toyed with Denver's sloppy defense. Nuggets opens at San Franciscos Chase Center on Saturday, April 16. The Denver Nuggets and the Golden State Warriors will play Game 2 of their first-round playoff series in the Western Conference on Monday night in San Francisco. A lot of teams are having to make concessions and doing different things just to keep the league moving while we go through this. Nuggets schedule, TV channels Warriors vs. “They don’t have to go anywhere and we have to make a special trip there,” Kerr said at the time. Back when the rescheduled date was announced in January, Kerr expressed his own frustration of the game’s new timing - a day off before a game against the Clippers - and noted it was “a lot tougher for us than for Denver.” NBA AWARDS 2022: List of winners for MVP, Rookie of the Year and more What. The NBA game between the Golden State Warriors and Denver Nuggets will take place at Chase Center in San Francisco, California on Friday, October 21 at 10:00 PM ET. Nuggets, including a full schedule for the first-round series. The “certain teams” in question here is specifically one team: the Golden State Warriors. Heres everything you need to know about Warriors vs. Sunday, June 18 NBA Finals - Game 7: Heat at Nuggets, 8 p.m., ABC (if necessary) NBA playoff result Friday, June 9 NBA Finals - Game 4: Nuggets 108, Heat 95 (Denver leads 3-1) Wednesday, June. All the games that were canceled and rescheduled affected everybody including us.” What was supposed to be a two-game road trip became a six games in nine days road trip. “We went to New York City three times this year. At Sacramento then home to play Golden State. The last part of that 4 in 5 is the most dreaded back to back in the NBA. “Certain teams think that when games are rescheduled it only affects one team,” Malone told reporters, according to Harrison Wind of DNVR Sports. ![]() ![]() In this post, you’ll find tips and tricks for acing such interviews based on my research and experience. Despite ethical concerns raised about the evaluation process, many big companies use it in their screening process and rely on AI to make their decisions. Filter Found 734 of over 734 interviews Sort Popular Popular Most Recent Oldest first Easiest Most Difficult Interviews at Warner Bros. Discovery Interview Questions Updated Find Interviews To filter interviews, Sign In or Register. If we have curiosity, we will be open to learning and implementing new things. Communication, Teamwork, Problem Solver ). 30 Photos 900 Diversity + Add an Interview Warner Bros. And we must have curiosity because we will continually encounter different customs and cultures, as well as changes or advancements in treatments and medical equipment. Found 736 of over 736 interviews Sort Popular Popular Most Recent Oldest first Easiest Most Difficult Interviews at Warner Bros. Compassion is a must, as nurses are often seeing patients during a very difficult time in the patient's life. ![]() Although this was very challenging at first, I became very efficient at assessing and administering nighttime medications to one set of patients and completing all of my charting for these patients within 4 hours. When I worked as a travel nurse, I sometimes took care of one set of patients from 1900-2300, and then I was floated to a different unit for the remainder of my shift (2300-0700). Nurses must be flexible to handle shifts in staffing, changes in a patient's condition, and even a brand new assignment during their shift. We could always do with more help and wisdom, friend! The better the FAQ, the harder we can come down on lazy posters with low-effort OPs, which means a higher quality subreddit experience for you."The top three skills needed to be an excellent nurse are flexibility, compassion, and curiosity. The preparation should be strategic, it should begin with an understanding of the company, job role, and culture of the. Third: Search for prior posts on the subjectĬS Interview Questions Contribute to the FAQ! Second: Check the FAQ (work-in-progress, not actually useful yet, I'll remove this comment when it is) Instead, HireVue sends you a series of interview questions youll answer via video on your laptop, tablet, or smartphone. For starters, youre not actually interviewing with a real human. Good question! It's like this: if the question is more about college/university, it goes here if it's more about a job, it goes there if it's in between, it can go in either one.Įxamples of questions that can go in either would be, "Are college career fairs worth it?" or "What do you actually use from CS classes in real jobs?" or "Someone gave me this advice about getting an internship, is this right?" For more details, check out the rules. How does it work When you hear someone say video interview, you probably think of a Skype interview. Wait, what goes here vs /r/cscareerquestions? U/flopsythesecond is the moderator for this discord, and should be contacted if you have any trouble with it. The following discord is not officially affiliated or managed by this sub, but it is related and the person running it has been nice about asking as well as persistent, so into this sidebar it goes: discord.gg/csmajors Please keep the conversation semi-professional or better, adhere to the reddiquette, and remember to READ OUR RULES. Here we discuss university-level and other education in Computer Science, Computer Engineering, Software Engineering, and related majors. ![]() To capture an image of your Android device, use your computer.Quickly and simply connect your gadgets.You Might Like Eassos PartitionGuru Crack ScreenShots: What’s New In AirDroid Keygen? 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If you didn’t pin it, scroll down to find all menu options.Once you’ve pinned any three things to your customized menu: You can update your NBA LIVE 18 & 19 info on ea.com. Your EA Account email address will be at the top of the screen. Need to update the email address linked to your EA Account? Learn how to update your account info. You’ll see the email address tied to your EA Account at the top of the screen. From the main menu, scroll to the right until you see the three dots icon.Sign in with your PlayStation ID or Xbox gamertag.Here you’ll find your public ID, your email address that’s linked to your EA Account, and your join date. These steps are for console games (PlayStation and Xbox) only. ![]() If you don’t have access to your email address, don’t remember what the full address is, or don’t have access to your EA Login Verification methods, see how to get help with your account. 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Steam search by email, if offered to you, can be considered as a fraudulent activity and you should never trust third party services.See how you can find your email address in your account settings, or in the menu of some of your favorite games on PlayStation and Xbox.Īre you trying to log in to your EA Account but forgot your email address or password? We’ve got you covered. Steam never discloses emails of users by any circumstances and any data breaches can lead to serious legal consequences. If someone promises you such services, most probably they are scammers. Neither can you find Steam id by email or find a trustworthy Steam email finder. Leave the website or app immediately, especially if they ask you to pay for using their services. The most alarming red flag you must notice if you enter a third party service to help you out with Steam ID formats is the search Steam users by email. It is much safer not to perform this type of search and use such services like SteamID Pro for finding necessary formats to join the servers. However, there is a danger of a data breach that can result in you losing your account or giving it to fraudsters. As well, you might feel anxious if someone can someone find my Steam account name via email, we can assure you that it’s impossible. Steam email address finder is a rather a myth. Some dangers to find someones steam email ![]() Emails are known only to the profile owners and even if you disclosed this information to someone, you can be safe. If you still wonder how to find out someones Steam email with their Steam ID or invite link, we would also indicate that it is impossible. If you have any problems with remembering the email it is better to contact Steam Support, rather than ask for third party websites to find it for you. Second of all, your own email address you can easily check in your account details. First of all, one’s email is considered to be private information regardless of private or public account type. However, Steam email finder is a rarity out there.Īs we mentioned previously, Steam user search by email is impossible due to various reasons. SteamID Pro is the best choice for finding your original Steam ID, invite link, or any other format for you. ![]() The standard search results of SteamID Pro consist of old and new formats of the user's profile you might need to join the server or add for whitelisting. Any other methods would be considered as illegal or fraudulent and we will go through this problem later in the post. Even with the best services like SteamID Pro, you can find the account ID or invite link only by having their vanity URL. There are a variety of ways to find Steam members but it is impossible to find Steam user by email. Let’s say you have your friend’s email but you forgot their nickname, you start to wonder how to find someone on Steam with their email. ![]() Good renders need good lighting, and good lighting can sometimes be difficult to achieve. Everything’s going to be the same material. If your imported model isn’t broken up into different parts, there’s nothing you can do about it in KeyShot. KeyShot applies materials on a per-part basis. If you can pull in models with standardized material names, this will save you a ton of time. You don’t have to manually apply, say, the shiny black plastic material to all your shiny black plastic parts KeyShot will recognize the name of the imported material and automatically apply the correct KeyShot material. To help you optimize your pipeline, KeyShot lets you create texture templates that will automatically map imported texture X to KeyShot texture Y. 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There are dozens of ready-made templates available so you can get started right away. It provides a drag-and-drop form builder that enables you to quickly and easily create stunning and useful order forms. ![]() The Fluent Forms plugin for WordPress is one of the most popular and affordable order form plugins on the market and for good reason. |
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